Active Clinical Trials

Clinical trials are at the heart of our work to bring innovative medicines to people with a particular disease or condition. Learn more about the active studies conducted by Novartis including opportunities to get involved.

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Study title Condition Phase Location

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

 		Sickle Cell Disease Phase3 United States NCT06439082

ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients

 		Multiple Sclerosis, Relapsing-Remitting Italy NCT06345157

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

 		Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, HR+/HER2- Ductal and Lobular Breast Cancer, Triple Negative Breast Cancer, Colorectal Cancer Phase1 Israel NCT06562192

Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

 		Scleroderma, Diffuse Phase2 Singapore
United States 		NCT06655896

Real-world Experience With Lutetium Vipivotide Tetraxetan in Metastatic Castration Resistant Prostate Cancer

 		Metastatic Castration Resistant Prostate Cancer Germany NCT06517719

A Non-interventional Study Evaluating Clinical Utility and Implications on Improved Patient Management of Serum Neurofilament as a Prognostic Marker for Disease Activity in Patients With Relapsing Multiple Sclerosis

 		Multiple Sclerosis Germany NCT06551519

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

 		Healthy Volunteers, Pulmonary Arterial Hypertension Phase1, Phase2 United States NCT06649110

Specified Drug-use Surveillance of Fabhalta Capsules

 		Paroxysmal Nocturnal Hemoglobinuria Japan NCT06606314

A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)

 		Amyotrophic Lateral Sclerosis (ALS) Phase2 United States NCT06643481

An Ascending Dose Study of PIT565 in Participants With Systemic Lupus Erythematosus (SLE).

 		Systemic Lupus Erythematosus, SLE Phase1 Spain NCT06335979